State Championships: 1956, 1991, 1997, 1998, 1999, 2007, 2011 (Academic)
| 1991 DeSales High School WIAA State B-11 Football Champions |
| 1998 Desales High School WIAA State B-11 Football Champions |
| 1999 DeSales High School WIAA State B-11 Football Champions |
| 2007 DeSales High School WIAA State B-11 Football Champions |
2010 (Academic)
State Championships: 1999, 2004 (Academic)
| Boys Track & Field State "A" Champions | |||
| Event | Name | Time/Mark | Year |
| 200 Meter Run | John Leier | 22 | 1970 |
| 3200 Meter Run | Marty Gwinn | 09:51.6 | 1973 |
| Javelin | Gerald Lyons | 223' 4 1/2" | 1978 |
| Boys Track & Field State "B" Champions | |||
| 200 Meter Run | Casey Richard | 22.7 | 2000 |
| 400 Meter Run | Casey Richard | 50.7 | 1999 |
| 800 Meter Run | Jerry Close | 01:59.2 | 1995 |
| 100 Hurdles (STATE & SCHOOL RECORD) | Nick Wales | 38.87 | 2012 |
| High Jump | Jamahl Fitzgerald | 6' 7" | 1999 |
| Javelin | Jamen Elmer | 173' 9" | 1999 |
| STATE RECORD!!! | Nick Lyons | 198' 10" | 2006 |
| Nick Lyons | 188' 8" | 2007 | |
| Boys "B" State Champions: | Jamahl Fitzgerald, Von Baer, Keith Michels, Tony Daltoso, Shaun Sung,Casey Richard, Jeff Murray, Matt Stacey | 1999 | |
| Academic State Champions: | Chad Acock, Jim Caulk, James Crosby, Sam Donnelly, Chirs Michels, Travis Klicker, Dylan Tokar, Micah Thoms, Tony Sutlick, Alex Wentz, Jordan Bennett, Tim Wade, Chris Wujek, Trent Sislow, Andrew Torrey | 2004 | |
| DeSales Boys Track & Field Record | |||
| Event | Name | Time/Mark | Year |
| 100 Meter Run | John Leier | 10.9 | 1970 |
| 200 Meter Run | John Leier | 22 | 1970 |
| 400 Meter Run | John Leier | 48.7 | 1970 |
| 800 Meter Run | S. Gwinn | 01:58.6 | 1963 |
| 1600 Meter Run | Tim Esser | 04:23.7 | 1970 |
| 3200 Meter Run | Marty Gwinn | 09:51.6 | 1973 |
| 100 Meter Hurdles | Dave Lentz | 15.3 | 1967 |
| 300 Meter Hurdles | Marc Dunn | 39.6 | 1982 |
| Shot Put | Frank Talerico | 53' | 1967 |
| Discus | Chris Schamer | 171' 9" | 1983 |
| Javelin | Gerald Lyons | 223' 4 1/2" | 1972 |
| Long Jump | Dick Heinzman | 21' 5" | 1972 |
| Triple Jump | Tim Beechie | 41' 9" | 1976 |
State Championship: 1992, 2017
| Girls Track & Field State Champions | |||
| Event | Name | Time/Mark | Year |
| 300 Meter Hurdles | Andrea Wujek | 46.2 | 2004 |
| 400 Meter Run | Katelyn Hassler | 56.09 | 2019 |
| Sarah Levens | 58.2 | 1993 | |
| Sarah Levens | 59.1 | 1994 | |
| 800 Meter Run | Jennie Close | 02:20.5 | 1992 |
| Lucrecia Cervantes | 02:19.5 | 2004 | |
| 800 Meter Relay (4x200) | Jenny Close, Suzanna Scudder, Jamie Murray, Megan Waldher | 1:49.0 | 1992 |
| Margot Robison, Lucrecia Cervantes, Ashley Cox, Andrea Wujek | 1:49.14 | 2002 | |
| Margot Robison, Lucrecia Cervantes, Ashley Cox, Andrea Wujek | 01:47.1 | 2004 | |
| 1600 Meter Relay (4x400) | Megan Waldher, Suzanna Scudder, Jamie Murray, Jenny Close | 4:08.2 | 1992 |
| Leticia Cervantes, Stephanie Wolfram, Andrea Wujek, Lucrecia Cervantes | 04:03.5 | 2003 | |
| STATE RECORD!!! | Leticia Cervantes, Stephanie Wolfram, Andrea Wujek, Lucrecia Cervantes | 04:01.4 | 2004 |
| 3200 Meter Run | Jennie Close | 11:49.1 | 1992 |
| Janel Sislow | 11:58.2 | 2004 | |
| DeSales Girls Track & Field Records | |||
| Event | Name | Time/Mark | Year |
| 100 Meter Run | Sarah Levens | 12.78 | 1994 |
| 200 Meter Run | Sarah Levens | 26.35 | 1994 |
| 400 Meter Run | Sarah Levens | 58.2 | 1993 |
| 800 Meter Run | Lucrecia Cervantes | 02:19.2 | 2004 |
| 1600 Meter Run | Cheryle Cowell | 05:24.4 | 1986 |
| 3200 Meter Run | Jenny Close | 11:49.1 | 1992 |
| 100 Meter Hurdles | Andrea Wujek | 14.82 | 2005 |
| 300 Meter Hurdles | Andrea Wujek | 45.78 | 2005 |
| Shot Put | Jena Worth | 41' 2 1/2" | 2003 |
| Discus | Theresa Postlewait | 125' 8" | 1997 |
| Javelin | Mackenzie Lilwall | 125' 8" | 2001 |
| Long Jump | Patti Tompkins | 17' 8" | 1982 |
| Triple Jump | Jenny Dutton | 33' 11 1/2" | 1998 |
| High Jump | Erin Hellberg | 5' 2" | 1995 |
| Pole Vault | Megan Notturno | 10' 3" | 2005 |
| 400 Meter Relay | Sarah Levens, Suzanna Scudder, Megan Walder, Julie Wicher | 51.2 | 1993 |
| 800 Meter Relay | Margot Robison, Leticia Cervantes, Lucrecia Cervantes, Andrea Wujek | 1:47.07 | 2004 |
| 1600 Meter Relay | Leticia Cervantes, Andrea Wujek, | ||
| STATE RECORD! | Stephanie Wolfram, Lucrecia Cervantes | 04:01.4 | 2004 |
State Championship: 2012
State Championships (17 titles over a span of four decades): 1989, 1992, 1993, 1994, 1995, 1996, 1997, 1998, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2008, 2012